A degron-mimicking molecular glue drives CRBN homo-dimerization and degradation

ABSTRACT: Cereblon (CRBN) is a ubiquitin ligase widely harnessed for targeted protein degradation. We report the discovery of a molecular glue that drives CRBN homo-dimerization and subsequent fast, potent, and selective CRBN degradation by the ubiquitin proteasome system. The structure of the complex reveals a unique mechanism whereby two molecular glues assemble into a helix-like structure and drive ternary complex formation by mimicking a protein degron in trans.

INSTRUMENT(S):

ORGANISM(S): Mus Musculus (mouse)

TISSUE(S): Monocyte, Ascites

SUBMITTER: Despoina Kapsitidou  

LAB HEAD: Debora Bonenfant

PROVIDER: PXD065335 | Pride | 2025-09-08

REPOSITORIES: pride