Proteomics

Dataset Information

0

2E7 Antigen Identification Using PhAbomics Technology


ABSTRACT: Antibody–drug conjugates (ADCs) require antibodies with both high specificity and efficient internalization—features often overlooked by conventional discovery pipelines that rely on preselected antigens and recombinant proteins. Here, we present an integrated phenotypic platform that combines target-unbiased live-cell biopanning with in situ chemical crosslinking and mass spectrometry to concurrently identify internalizing 49 antibodies and their membrane-bound cognate antigens in a physiologic context.

INSTRUMENT(S):

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Cell Culture

SUBMITTER: Eugene YI  

LAB HEAD: Eugene C

PROVIDER: PXD065365 | Pride | 2025-11-20

REPOSITORIES: Pride

Dataset's files

Source:
Action DRS
20170408_2E7_CSC_FN01_01.mgf Mgf
20170408_2E7_CSC_FN01_01.mzXML Mzxml
20170408_2E7_CSC_FN01_02.mgf Mgf
20170408_2E7_CSC_FN01_02.mzXML Mzxml
20170410_2E7_CSC_FN02_01.mgf Mgf
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