Cornulin, a potential prognostic biomarker in head and neck squamous cell carcinoma, acts as an anti-tumour agent by inhibiting cell cycle through upregulation of p18.

ABSTRACT: The xenograft models were developed using 4–6-week-old CD1-Foxn1nu nude male mice and subcutaneously inoculating HNSCC cell lines, i.e., Cal27. In each mouse, the left flank received Cal27 untreated cells and the right flank received Cal27 Cornulin-overexpressing cells to allow within-animal comparison. After tumor development, mice were sacrificed, and xenograft tumors were excised. Tumor tissues were then subjected to protein extraction, tryptic digestion, and LC-MS/MS-based proteomic analysis to identify differentially expressed proteins associated with Cornulin overexpression in vivo.

INSTRUMENT(S):

ORGANISM(S): Homo Sapiens (human) Mus Musculus (mouse)

TISSUE(S): Epithelial Cell

DISEASE(S): Head And Neck Squamous Cell Carcinoma

SUBMITTER: Arnab Pal  

LAB HEAD: Arnab Pal

PROVIDER: PXD065385 | Pride | 2025-07-16

REPOSITORIES: Pride