Proteomics

Dataset Information

0

Identification of BIK1-targeted phosphorylation sites on NLRs

ABSTRACT: BIK1 is a central regulator of signaling downstream of the activation of patter recognition receptors and may represent a functional link between pattern- and effector- triggered immunity in plants. Among myriad BIK1 substrates are several intracellular immune receptors. This project aims to map BIK1-targeted phosphorylation sites on two such receptors.

INSTRUMENT(S):

ORGANISM(S): Escherichia Coli

SUBMITTER: Kyle W. Bender  

LAB HEAD: Prof. Dr.

PROVIDER: PXD065397 | Pride | 2026-03-02

REPOSITORIES: Pride

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Dataset's files

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Action DRS
20250530_009_S950061_RPS5_WT_1.raw Raw
20250530_010_S950062_RPS5_WT_2.raw Raw
20250530_011_S950063_RPS5_WT_3.raw Raw
20250530_012_S950064_RPS5_KD_1.raw Raw
20250530_013_S950065_RPS5_KD_2.raw Raw
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Publications

Motif-based substrate mapping of the receptor-like cytoplasmic kinase BIK1 reveals novel components and regulatory nodes of plant immunity.

Toth Ryan R   Choi Sera S   Le Naour-Vernet Marie M   Schwanke Florian F   Johnson Jared L JL   Tee Estee E EE   Yaron-Barir Tomer M TM   Khochaba Eleanor E   Derbyshire Paul P   Colo Anka A   Köster Philipp P   Huntsman Emily M EM   Herold Laura L   Lee Yoonyoung Y   Fernández-Fernández Álvaro D ÁD   Ahn Hee-Kyung HK   Dindas Julian J   Bjornson Marta M   Rhodes Jack J   Song Beibei B   Wang Weibing W   Smokvarska Marija M   Bayer Emmanuelle M EM   Zhou Jian-Min JM   Cantley Lewis C LC   Jones Jonathan D G JDG   Bender Kyle W KW   Menke Frank L H FLH   Faulkner Christine C   Zipfel Cyril C   DeFalco Thomas A TA  

Nature plants 20260209

Plant cell surface pattern recognition receptors (PRRs) perceive non- or altered-self elicitors to induce immune responses. PRRs relay information across the plasma membrane and trigger downstream signalling via receptor-like cytoplasmic kinases such as BOTRYTIS-INDUCED KINASE 1 (BIK1). BIK1 associates with several PRRs and acts as a key executor of immune responses through the phosphorylation of substrate proteins. However, a comprehensive understanding of how BIK1 targets specific substrates a  ...[more]

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