Dataset Information
UD1long pulldown from HeLa Cell Extract
Ontology highlight
ABSTRACT:
INSTRUMENT(S):
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Epithelial Cell
DISEASE(S): Cervix Carcinoma
SUBMITTER: 
Joseph Harrison
LAB HEAD: Joseph S Harrison
PROVIDER: PXD065412 | Pride | 2025-12-11
REPOSITORIES: Pride
Dataset's files
| Action | DRS | |||
|---|---|---|---|---|
| JH-UD2-2.raw | Raw | |||
| JH-UD2.raw | Raw | |||
| JH-control.raw | Raw | |||
| JH-control1.raw | Raw | |||
| Skyline-pulldown-files.zip | Other |
Items per page: 1 - 5 of 7 |
Publications
Linked-domain inhibitors designed to block UBE2D induce the unfolded protein response.
Cell chemical biology 20251205 12
Ubiquitin (Ub) is a protein post-translational modifier that controls proteostasis through mechanisms spanning transcription, translation, and protein degradation. Ub conjugation occurs through a cascade of three enzyme classes (E1, E2, and E3s) involving >1,000 proteins that regulate the ubiquitination of cellular proteins. The E2 Ub-conjugating enzymes are the midpoint, yet their cellular roles remain under-characterized. Here, we develop highly selective and potent pan-UBE2D/UBCH5 inhibitors ...[more]
