Inhibition of AhR improves cortical bone and skeletal muscle function via preservation of neuromuscular junctions

ABSTRACT: This project aimed to assess the role of pharmacological inhibition of the aryl hydrocarbon receptor (AhR) on skeletal muscle and cortical bone health in aged mice. As part of a broader systems biology approach, proteomic profiling was employed to investigate molecular mediators of neuromuscular junction (NMJ) function in skeletal muscle tissue. The study compared vehicle-treated versus BAY2416964-treated aged mice, revealing key differentially expressed proteins involved in axonal development and NMJ stability.

INSTRUMENT(S):

ORGANISM(S): Mus Musculus (mouse)

TISSUE(S): Smooth Muscle, Fibroblast

DISEASE(S): Disease Free

SUBMITTER: Wenbo Zhi  

LAB HEAD: McGee Lawrence, Meghan

PROVIDER: PXD065529 | Pride | 2025-07-06

REPOSITORIES: Pride