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LC-MS targeting the UBAP2L-immunoprecipitated human gastric cancer cell extracts

ABSTRACT: We identified UBAP2L physiologically G3BP1 and RACK1.

INSTRUMENT(S):

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Permanent Cell Line Cell, Cell Culture

DISEASE(S): Gastric Adenocarcinoma

SUBMITTER: Chaorui Wu

LAB HEAD: Guoxin Li

PROVIDER: PXD065770 | Pride | 2026-02-09

REPOSITORIES: Pride

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			Action	DRS
	EV-Proteins.xlsx	Xlsx
	IP.raw	Raw
	IgG-Proteins.xlsx	Xlsx
	IgG.raw	Raw
	checksum.txt	Txt

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Publications

UBAP2L-driven stress granule formation links oxaliplatin resistance to gastric cancer.

Wu Chaorui C Yan Yu Y Chen Qichen Q Lian Zhiying Z He Jiayong J Ling Ruoyu R Lei Xuetao X Peng Yanmei Y Zheng Boyang B Yang Qingbin Q Ye Gengtai G Ma Wenhui W Li Guoxin G

Communications biology 20250813 1

Stress granules (SGs), which are phase-separating organelles that serve as protective cellular mechanisms in response to various harmful stimuli, have an unclear role in oxaliplatin resistance. Here, we establish a causal link between SG formation and oxaliplatin resistance in GC. Notably, we identify a key SG nucleator, namely, ubiquitin-associated protein 2-like (UBAP2L), as a previously unrecognized critical factor in mediating oxaliplatin resistance. UBAP2L-nucleated SG-mediated inhibition o ...[more]

PMID: 40804300

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