Proteomics

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Target profiling of organoplatinum(II) complex reveals role of protein tyrosine phosphatase 1B in modulating immunogenicity

ABSTRACT: Immunogenic cell death (ICD) inducers are valuable chemotherapeutic agents that elicit protective immune responses against tumors. However, the specific molecular targets directly associated with ICD remain less explored. Here, a Type II ICD inducer, Pt-ER, was validated as a bona fide ICD inducer with the ability to establish protection against colorectal cancer. Based on Pt-ER, several ICD-inducing photoactivable probes were designed to capture their potential targets. By integrating quantitative proteomics analysis, genetic method and biochemical assays, we identified that PTP1B is a direct target of Pt-ER and engages in ICD.

INSTRUMENT(S):

ORGANISM(S): Homo Sapiens (human)

SUBMITTER: Jiao Xia Zou  

LAB HEAD: Wee Han Ang

PROVIDER: PXD065824 | Pride | 2026-02-02

REPOSITORIES: Pride

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20240321_lumos_SG_NUSjiaoxia_7F.msf Msf
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Publications

Organoplatinum(II) Type II Immunogenic Cell Death Inducers Target Protein Tyrosine Phosphatase 1B to Drive Immunogenicity.

Zou Jiao Xia JX   Ivanov-Rostovtsev Pavel A PA   Arakelyan Jemma J   Babak Maria V MV   Ang Wee Han WH  

Journal of the American Chemical Society 20251223 2

Immunogenic cell death (ICD) inducers are valuable chemotherapeutic agents that elicit protective immune responses against tumors. Although many ICD inducers have emerged in recent years, specific molecular targets directly associated with ICD remain relatively unexplored. Here, two Type II ICD inducers, <b>Pt-NHC</b> and <b>PlatinER</b> (<b>Pt-ER</b>), were validated as <i>bona fide</i> ICD inducers with the ability to establish immunity against colorectal cancer <i>in vivo</i>. Based on <b>Pt-  ...[more]

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