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Identification of Khib substrates of histone regulated by NAT10

ABSTRACT: Having established NAT10’s regulatory role in lysine 2-hydroxyisobutyrylation, we aimed to identify the histone Khib sites targetedby NAT10. To this end, we extracted and digested core histones from cells with or without NAT10 depletion, followed by chemical derivatization of amine groups. The resulting peptides were analyzed by data-independent acquisition (DIA) mass spectrometry to detect the NAT10-modulated Khib sites.

INSTRUMENT(S):

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Hepatocyte, Liver

DISEASE(S): Liver Cancer

SUBMITTER: siyu wang

LAB HEAD: Kai Zhang

PROVIDER: PXD066039 | Pride | 2026-01-27

REPOSITORIES: Pride

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			Action	DRS
	checksum.txt	Txt
	histone-DIA-NAT10-KD-1.raw	Raw
	histone-DIA-NAT10-KD-2.raw	Raw
	histone-DIA-NAT10-KD-3.raw	Raw
	histone-DIA-PLKO-1.raw	Raw

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