PROTAC repurposing uncovers a noncanonical binding surface that mediates chemical degradation of nuclear receptors

ABSTRACT: MD-224 is a PROTAC that induces degradation of the human protein MDM2. However, we have found that it also induces degradation of a subset of nuclear receptors. DIA was performed to assess the overall specificity of MD-224 in 293T cells and the colorectal cancer cell line SNU-C4.

INSTRUMENT(S):

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Colon, Kidney

SUBMITTER: Zuo-Fei Yuan  

LAB HEAD: Anthony A High

PROVIDER: PXD066110 | Pride | 2025-09-18

REPOSITORIES: Pride