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Novel CDK-independent function of CDC25 phosphatases in mRNA translation

ABSTRACT: Investigating CDC25A interacting proteins and identifying new CDC25A substrates.

INSTRUMENT(S):

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Cell Culture

SUBMITTER: Emilie-Fleur GAUTIER

LAB HEAD: Stéphane Manenti

PROVIDER: PXD066262 | Pride | 2026-07-15

REPOSITORIES: Pride

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			Action	DRS
	Result.zip	Other
	StMA241106_CDC25A_SS192_DOX_HA_DetRem_E54552_RO10_1_3846.d.zip	Other
	StMA241106_CDC25A_SS192_Ni_HA_DetRem_E54544_RO2_1_3830.d.zip	Other
	StMA241106_CDC25A_SS196_DOX_HA_DetRem_E54549_RO7_1_3840.d.zip	Other
	StMA241106_CDC25A_SS196_Ni_HA_DetRem_E54557_RO15_1_3856.d.zip	Other

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Publications

Novel CDK-independent function of CDC25 phosphatases in mRNA translation.

Shin Sauyeun S Cargnello Marie M Pinchedé Lisa L Medale Giamarchi Claire C Villette Cléa C Gay Alexandre A Salnot Virginie V Gautier Emilie-Fleur EF Dassi Erik E Millevoi Stefania S Cammas Anne A Manenti Stéphane S

EMBO reports 20260714

Molecular and functional networks driving coordination between cell cycle and mRNA translation remain to be explored. Here, we use mass spectrometry-based proteomics to comprehensively investigate the interactome and phosphoproteome of the cell cycle regulator CDC25A. We identify actors of mRNA regulation, such as RNA-binding proteins and translation factors, as interacting partners of CDC25A. CDC25A overexpression increases global translation, whereas catalytic inactivation or pharmacological i ...[more]

PMID: 42448957

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