Dataset Information

Proteomic analysis of ARVC rat with PKP2 mutation heart

ABSTRACT: To investigate the changes in sodium channel proteins in ARVC rats with PKP2 gene mutations, we performed proteomic analysis on the hearts of WT and PKP2 rats.

INSTRUMENT(S):

ORGANISM(S): Rattus Norvegicus (rat)

TISSUE(S): Heart, Cardiac Muscle Cell

DISEASE(S): Arrhythmogenic Right Ventricular Cardiomyopathy

SUBMITTER: Hui Zhang

LAB HEAD: Hui Zhang

PROVIDER: PXD066271 | Pride | 2025-08-25

REPOSITORIES: Pride

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Publications

Machine learning analysis of ARVC informed by sodium channel protein-based interactome networks.

Zhu Yanan Y Zhang Hui H Zhao Xuan X Wang Xin X Xing Lina L Yao Sijie S Jin Xiao X Li Tingting T Dai Ting T Ding Xinyue X Qi Zhen Z Liu Zongjun Z

Frontiers in pharmacology 20250723

<h4>Background</h4>Arrhythmogenic right ventricular cardiomyopathy (ARVC) is an inherited cardiac disorder characterized by sodium channel dysfunction. However, the clinical management of ARVC remains challenging. Identifying novel compounds for the treatment of ARVC is crucial for advancing drug development.<h4>Purpose</h4>In this study, we aim to identify novel compounds for treating ARVC.<h4>Methods</h4>Machine learning (ML) models were constructed using proteins analyzed from the scRNA-seq d ...[more]

PMID: 40771922

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