Integrated Fibre-Specific Methylome and Proteome Profiling of Human Skeletal Muscle Across Males and Females with Fibre-Type Deconvolution.
Ontology highlight
ABSTRACT:
INSTRUMENT(S):
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Skeletal Muscle, Type Ii Muscle Cell, Type I Muscle Cell
SUBMITTER: 
Joel Steele
LAB HEAD: : Prof. Nir Eynon
PROVIDER: PXD066393 | Pride | 2025-10-13
REPOSITORIES: Pride
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Integrated fibre-specific methylome and proteome profiling of human skeletal muscle across males and females with fibre-type deconvolution.
Palmer Andrew S AS García-Domínguez Esther E Taylor Megan F MF Garnham Andrew A Seale Kirsten K Steele Joel R JR Lee Han-Chung HC Schittenhelm Ralf B RB Eynon Nir N
Skeletal muscle 20251010 1
<h4>Background</h4>Skeletal muscle is an important organ for health and movement, largely driven by specific muscle fibres. However, the comparison of fibre-type-specific DNA methylation and protein abundance from the same sample presents challenges. By combining previous methodological approaches we were able to directly compare the methylome and proteome in Type I and Type II human skeletal muscle fibres in males and females.<h4>Methods</h4>We assessed the methylome using the EPICv2 Infinium a ...[more]
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