Dataset Information

Integrated landscape of renal metabolism in domestic cats with spontaneous chronic kidney disease: a multi-omics study

ABSTRACT: Chronic kidney disease (CKD) is the leading cause of mortality in aged cats. After injury, feline kidneys undergo extensive metabolic reprogramming, but a comprehensive evaluation is lacking. Integration of serum metabolome from early stages, late stages CKD and healthy control cats with renal cortex and medulla transcriptome and proteome can reveal spatiotemporal patterns of gene and protein expression changes. In this study, we conducted mass spectrometry (MS)-based proteomic analysis of kidney (cortex and medulla) tissues from cats with CKD and control cats, euthanized for humane reasons unrelated to the study.

INSTRUMENT(S):

ORGANISM(S): Felis Catus (cat) (felis Silvestris Catus)

TISSUE(S): Renal Cortex, Renal Medulla, Kidney

DISEASE(S): Kidney Disease,Chronic Kidney Disease

SUBMITTER: Loïc Dayon

LAB HEAD: Loïc Dayon

PROVIDER: PXD066590 | Pride | 2025-10-14

REPOSITORIES: Pride

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Dataset's files

Source:

			Action	DRS
	Cat_Cortex_MERGE_All_ref_1_28.xls	Xls
	Cat_Medulla_MERGE_All_ref_m1_28.xls	Xls
	Exp10_Pool_1_14_m10_m11_m14_m1_Pool_1_28_01.raw	Raw
	Exp10_Pool_1_14_m10_m11_m14_m1_Pool_1_28_01_F090801.MGF	Mgf
	Exp10_Pool_1_14_m10_m11_m14_m1_Pool_1_28_02.raw	Raw

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Integrated multi-omics analysis of renal metabolism in domestic cats with spontaneous chronic kidney disease.

Li Qinghong Q Cominetti Ornella O Holzwarth James A JA Summers Stacie S Wang Xu X Dayon Loïc L

Communications biology 20251213 1

Chronic kidney disease (CKD) is the leading cause of mortality in aged cats. After injury, feline kidneys undergo extensive metabolic reprogramming, but a comprehensive evaluation is lacking. Here we show a multi-omics study including serum metabolomics from 14 healthy control, 15 early stages, 6 late stages CKD cats, and renal cortical and medullary tissue RNA sequencing and proteomics. The analysis reveals a spatiotemporal pattern of gene and protein expression changes. In the early stages, th ...[more]

PMID: 41390888

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