Dataset Information

Proteomic analysis on human islet with treatment of a PERK inhibitor

ABSTRACT: Partial downregulation of pancreatic endoplasmic reticulum kinase (PERK) activity recovered insulin content in human islets exposed to glucolipotoxicity (GLT), resulting in improved insulin secretion and glucose-lowering effects in a mouse model of type 2 diabetes. We conducted this study to elucidate the beta-cell enhancing mechanisms of PERK attenuation.

INSTRUMENT(S):

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Pancreatic Islet Cell

SUBMITTER: Dohyun Han

LAB HEAD: Dohyun Han

PROVIDER: PXD066613 | Pride | 2026-06-29

REPOSITORIES: Pride

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Dataset's files

Source:

			Action	DRS
	20231214_PRIMARY_CELL_TMT_F.msf	Msf
	20231214_PRIMARY_CELL_TMT_F.msfView	Msf
	20231214_PRIMARY_CELL_TMT_F.pdResult	Other
	20231214_PRIMARY_CELL_TMT_F.pdResultView	Other
	20231214_PRIMARY_CELL_TMT_F1.raw	Raw

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Publications

Proteomic Analysis on Human Islets Suggests Nucleocytoplasmic Transport as a Mechanism of PERK Attenuation Effects in Diabetes.

Park Yeon Soo YS Yun Soeun S Sim Min Seop MS An Eun Jin EJ Lee Jin J Ha Eun Hee EH Jang Jin-Young JY Kwon Wooil W Han Dohyun D Jung Hye Seung HS

Molecular & cellular proteomics : MCP 20260518 6

Partial downregulation of pancreatic endoplasmic reticulum kinase (PERK) activity recovered insulin content in human islets exposed to glucolipotoxicity (GLT), resulting in improved insulin secretion and glucose-lowering effects in a mouse model of type 2 diabetes. We conducted this study to elucidate the beta-cell-enhancing mechanisms of PERK attenuation. Pancreatic islets isolated from non-diabetic living donors were divided into three groups: control, GLT mimicking diabetes conditions, and GL ...[more]

PMID: 42155730

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