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Oxidative Stress and Metabolic Plasticity of NOX-2 KO mice Hematopoitic Stem Cells Homeostasis Proteomics Profile

ABSTRACT: We investigated the contribution of NOX-2 to redox balance, mitochondrial respiration, and glycolytic compensation in lineage-negative Sca-1⁺c-Kit⁺ (SKL) bone marrow stem cells from wild-type (WT) and NOX-2 knockout (NOX2-KO) mice. Proteomic profiling identified differentially expressed proteins involved in hypoxic response, glycolysis, and oxidative stress adaptation between WT and NOX2-KO SKL cells.

INSTRUMENT(S):

ORGANISM(S): Mus Musculus (mouse)

TISSUE(S): Bone Marrow, Hematopoietic Stem Cell Differentiation

DISEASE(S): Disease Free

SUBMITTER: Kannathasan Thetchinamoorthy

LAB HEAD: Kannathasan Thetchinamoorthy

PROVIDER: PXD066664 | Pride | 2025-12-03

REPOSITORIES: Pride

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			Action	DRS
	Final_Data_WTVsNOX.csv	Csv
	NOX_1_A.mgf	Mgf
	NOX_1_B.mgf	Mgf
	NOX_1_C.mgf	Mgf
	NOX_2_A.mgf	Mgf

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