Phosphorylation of LARS (leucyl-tRNA synthetase) induced by amino acid stimulation

ABSTRACT: LARS undergoes structural changes in response to amino acid stimulation and translocates to lysosome, exhibiting non-canonical functions such as mTORC1 activation instead of its canonical function of tRNA amino-acylation. This study investigates which post-translational modifications (PTMs) of LARS occur during amino acid stimulation and how these modifications affect the non-canonical functions of LARS. We identified phosphorylation occurring at LARS residues S1070, S1077, and S1082.

INSTRUMENT(S):

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Epithelial Cell, Cell Culture

SUBMITTER: YOUJIN KIM  

LAB HEAD: Hee-Sung Park

PROVIDER: PXD066801 | Pride | 2026-04-06

REPOSITORIES: Pride