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Region-resolved proteomic analysis of mouse heart from different age groups

ABSTRACT: Aging is a major risk factor for cardiovascular diseases (CVDs), primarily due to its association with declining cardiac function, which significantly influences the pathogenesis of conditions like myocardial infarction and heart failure. While several cardiac proteomic atlases exist, spatially resolved proteomic dynamics essential for understanding region-specific cardiac aging mechanisms remain poorly characterized. This study establishes a spatially resolved quantitative proteomic atlas across multiple murine cardiac regions at three aging stages (3, 12, and 20 months). Using bioinformatics deconvolution and machine learning, we systematically identified key cardiac aging regulators from 6,650 quantified proteins. Collectively, this work provides an extensive region-resolved proteomic landscape of cardiac aging, identifies key protein regulators, and uncovers potential targets for cardio-protective interventions against age-related CVDs.

INSTRUMENT(S):

ORGANISM(S): Mus Musculus (mouse)

TISSUE(S): Heart, Fetal Cardiomyocyte

DISEASE(S): Cardiovascular System Disease

SUBMITTER: Lingyun Dai

LAB HEAD: Lingyun Dai

PROVIDER: PXD066926 | Pride | 2026-05-22

REPOSITORIES: Pride

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			Action	DRS
	20221124_HJN_mouse_heart_LV_middle_1.raw	Raw
	20221124_HJN_mouse_heart_LV_middle_1.raw.quant	Raw
	20221124_HJN_mouse_heart_LV_middle_2.raw	Raw
	20221124_HJN_mouse_heart_LV_middle_2.raw.quant	Raw
	20221124_HJN_mouse_heart_LV_middle_3.raw	Raw

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