Proteomic analysis of ANO10 SH-SY5Y mutant cell lines

ABSTRACT: To investigate the effects of ANO10 pathogenic variants in cell proteome, four SH-SY5Y mutant cell lines (a knockout cell line,and three lines bearing the following variants: ANO10 c.289delA, ANO10 c.1009T>G, and ANO10 c.1529T>G) were engineered via CRISPR-Cas9 editing. After establishment and characterisation, the cell lines were subjected to nanoLC-MS/MS proteomic analysis.

INSTRUMENT(S):

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Cell Culture

SUBMITTER: Frank Stein  

LAB HEAD: Kyproula Christodoulou

PROVIDER: PXD067059 | Pride | 2026-09-07

REPOSITORIES: Pride