Role of SPOP in cardiac hypertrophy and heart failure

ABSTRACT: Pressure overload-induced cardiac hypertrophy and heart failure involve profound remodeling of the myocardial proteome. To elucidate the role of the E3 adaptor protein SPOP in this process, we performed TMT-based quantitative proteomic analysis on left ventricular tissues collected four weeks after transverse aortic constriction (TAC) from Myh6-Cre control mice (n=5) and cardiac-specific SPOP knockout (cKO) mice (n=5).

INSTRUMENT(S):

ORGANISM(S): Mus Musculus (mouse)

TISSUE(S): Heart, Cardiac Muscle Cell

DISEASE(S): Heart Failure

SUBMITTER: Liu jiangqi  

LAB HEAD: Hao Wu

PROVIDER: PXD067120 | Pride | 2025-08-26

REPOSITORIES: Pride