Dataset Information

Extracellular vesicles derived from glial progenitor cells from human induced pluripotent stem cells

ABSTRACT: Extracellular vesicles are bubbles used by cells for intercellular and intertissue interactions. Their cargo includes various proteins, nucleic acids, peptides, which, interacting with cells, trigger intracellular cascades. Proteomic analysis of extracellular vesicles from different cell types has already been performed. Here, we present the first proteomic analysis of extracellular vesicles proteins obtained from three lines of glial progenitor cells differentiated from human induced pluripotent stem cells.

INSTRUMENT(S):

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Cell Culture

SUBMITTER: Georgij Arapidi

LAB HEAD: Georgij Arapidi

PROVIDER: PXD067360 | Pride | 2025-12-15

REPOSITORIES: Pride

ACCESS DATA

Dataset's files

Source:

			Action	DRS
	Goldshtein_20221122_Sh476-Sh478_ExtracellularVesicules_Experiment_Condensed.sf3	Other
	Sh-476.dat	Other
	Sh-476.mgf	Mgf
	Sh-476.mzid	Mzid
	Sh-476.mzid_Sh-476.MGF	Mzid

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Publications

Extracellular Vesicles from iPSC-Derived Glial Progenitor Cells Prevent Glutamate-Induced Excitotoxicity by Stabilising Calcium Oscillations and Mitochondrial Depolarisation.

Shedenkova Margarita M Gurianova Anastasiia A Krasilnikova Irina I Sudina Anastasia A Karpulevich Evgeny E Maksimov Yaroslav Y Samburova Marina M Guguchkin Egor E Nefedova Zlata Z Babenko Valentina V Frolov Daniil D Savostyanov Kirill K Fatkhudinov Timur T Goldshtein Dmitry D Bakaeva Zanda Z Salikhova Diana D

Cells 20251202 23

Neurodegenerative diseases pose a significant challenge to modern medicine. Despite significant advances in neurology, current therapeutic approaches often prove insufficient to treat such disorders. This study investigates the neuroprotective effect of extracellular vesicles derived from glial derivates of human-induced pluripotent stem cells. The extracellular vesicle's cargo was characterised by proteomic analysis. The neuroprotective effect was assessed using a model of glutamate excitotoxic ...[more]

PMID: 41369405

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