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Proteomic analysis of cow milk derived extracellular vesicles from cows with different insulin resistance stages

ABSTRACT: Cows were classified into dofferent insulin resisitance (IR) groups as low, moderate and high IR. Milk samples were collected and extracellular vesicles were isolated and proteomic cargo files were studies and compard among diffrent IR groups to identigy potential biomarkers.

INSTRUMENT(S):

ORGANISM(S): Bos Taurus (bovine)

TISSUE(S): Milk

SUBMITTER: Madhusha Prasadani

LAB HEAD: Prof. Alireza Fazeli

PROVIDER: PXD067365 | Pride | 2026-06-08

REPOSITORIES: Pride

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Dataset's files

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			Action	DRS
	060924_Fazeli_Suhashini_MEV_proteinGroups.txt	Txt
	240904_04_Orbi3_MS_SER_G60_T85_Fazeli_Subhashini_MEV_07.raw	Raw
	240904_06_Orbi3_MS_SER_G60_T85_Fazeli_Subhashini_MEV_03.raw	Raw
	240904_08_Orbi3_MS_SER_G60_T85_Fazeli_Subhashini_MEV_12.raw	Raw
	240904_10_Orbi3_MS_SER_G60_T85_Fazeli_Subhashini_MEV_08.raw	Raw

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1 - 5 of 14

Publications

Milk extracellular vesicles reveal insulin resistance status in peripartum dairy cows.

Prasadani Madhusha M Jaakson Hanno H Karis Priit P Muhandiram Subhashini S Henno Merike M Kuusik Sirje S Ling Katri K Rajapaksha Harinda H Ots Meelis M Andronowska Aneta A Pradeep Kodithuwakku Suranga S Volke Vallo V Fazeli Alireza A

The veterinary quarterly 20260501 1

The transition from gestation to lactation is a critical period that leads to insulin resistance (IR) in dairy cows. IR detection requires invasive sampling and laborious methods; therefore, novel and non-invasive approaches are essential. Extracellular vesicles (EVs) are nano-sized particles released by cells and are linked to disease pathophysiology. Hence, the present study aimed to explore the potential application of cow milk EVs (MEVs) in detecting IR in dairy cows. An intravenous glucose ...[more]

PMID: 42065931

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2026-05-29 | PXD077541 | Pride

Uterine fluid extracellular vesciles proteome in bovine clinical and subclinical endometritis

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Insulin deficiency distorts human pancreatic endocrine cell composition during development

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Cell envelope adaptation and minimal Tat translocation are functionally intertwined

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