VCPIP1 Drives Diabetic Cardiomyopathy by Deubiquitinating AMPKγ1 and Preventing AMPKα-γ Subunit Assembly in Cardiomyocytes
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ABSTRACT: Protein ubiquitination modifications contribute to cardiomyocyte homeostasis and pathophysiology in diabetic cardiomyopathy (DCM). Yet the roles of deubiquitinating enzymes (DUBs) in DCM remain poorly defined. Here, we aimed to clarify the regulatory function of a DUB, valosin-containing protein interacting protein 1 (VCPIP1), in DCM and uncover the molecular mechanisms.
INSTRUMENT(S):
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Heart
SUBMITTER:
liu guoxuan
LAB HEAD: XUE HAN
PROVIDER: PXD067421 | Pride | 2026-03-16
REPOSITORIES: Pride
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