Targeting Ubiquitin Signaling vulnerabilities in KEAP1-Inactivated Lung Cancer

ABSTRACT: Lung cancer cells rely on protein homeostasis regulators, especially within the ubiquitin-proteasome system (UPS), to sustain malignancy. Genetic alterations in UPS components, such as E3 ubiquitin ligases (E3s) and deubiquitinating enzymes (DUBs), are common and create context-dependent therapeutic dependencies. We have investigated how these changes drive tumor formation, we conducted CRISPR screens on metabolically stressed murine lung cancer models and identified specific cancer vulnerabilities, including KEAP1.

INSTRUMENT(S):

ORGANISM(S): Mus Musculus (mouse)

TISSUE(S): Lung

DISEASE(S): Lung Cancer

SUBMITTER: Rubina Kazi  

LAB HEAD: Prof. Ivan Dikic

PROVIDER: PXD067472 | Pride | 2026-02-04

REPOSITORIES: Pride