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Trigger Factor in Burkholderia pseudomallei is essential for key virulence determinants including host cell internalisation, cytotoxicity, motility and stress resistance.

ABSTRACT: Melioidosis is a potentially fatal infection caused by Burkholderia pseudomallei, a bacterium that is intrinsically resistant to many commonly used antibiotics. Therefore, the identification of new drug targets is essential for the development of new and effective therapies. This study demonstrates that the Trigger Factor protein, encoded by BPSL1402, is important for the establishment of B. pseudomallei infection and is involved in multiple facets of virulence including motility, cell cytotoxicity and resistance to stress. With reports of B. pseudomallei isolated from new regions and resistance to current treatment options, the significance of this research is the identification of a novel B. pseudomallei virulence factor that can be potentially exploited for the development of new therapeutics to treat this deadly infection.

INSTRUMENT(S):

ORGANISM(S): Burkholderia Pseudomallei (strain K96243)

SUBMITTER: Nichollas Scott

LAB HEAD: Dr Mitali Sarkar-Tyson

PROVIDER: PXD067556 | Pride | 2026-04-07

REPOSITORIES: Pride

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			Action	DRS
	20203030_Nsco_DDA_PASF_BP_WT_B1_GA1_1_389.d.zip	Other
	20203030_Nsco_DDA_PASF_BP_WT_B2_GA6_1_399.d.zip	Other
	20203030_Nsco_DDA_PASF_BP_WT_B3_GB3_1_369.d.zip	Other
	20203030_Nsco_DDA_PASF_BP_WT_B4_GB8_1_379.d.zip	Other
	20203030_Nsco_DDA_PASF_BP_delta_tig_B1_GA5_1_397.d.zip	Other

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