Mass spectrometry-based phosphoproteomics of PCMD-1

ABSTRACT: PCMD-1 is a centriolar protein that stabilizes the pericentriolar material (PCM) scaffold in C. elegans. Our data show that CDK-1 primes PCMD-1 for PLK-1–dependent phosphorylation. Mutations in PLK-1 docking sites reduce PCMD-1 phosphorylation, leading to disorganized PCM, unstable centrosomes, and delayed centriole separation. These findings suggest that PCMD-1 phosphorylation is essential for tethering and maintaining PCM scaffold integrity during mitosis.

INSTRUMENT(S):

ORGANISM(S): Caenorhabditis Elegans

SUBMITTER: Serena Schwenkert  

LAB HEAD: Serena Schwenkert

PROVIDER: PXD067573 | Pride | 2025-10-24

REPOSITORIES: Pride