Dataset Information

Proteome profiles in diabetic thoracic and abdominal aortas

ABSTRACT: This study provides a comprehensive atlas of how proteomic profiles are distinct in thoracic and abdominal aortas of spontaneously diabetic mice.

INSTRUMENT(S):

ORGANISM(S): Mus Musculus (mouse)

SUBMITTER: Chak Kwong Cheng

LAB HEAD: Chak Kwong Cheng

PROVIDER: PXD067688 | Pride | 2026-04-06

REPOSITORIES: Pride

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Dataset's files

Source:

			Action	DRS
	XA02350B2SA_Aor_dbAA1.raw	Raw
	XA02350B2SA_Aor_dbAA2.raw	Raw
	XA02350B2SA_Aor_dbAA3.raw	Raw
	XA02350B2SA_Aor_dbAA4.raw	Raw
	XA02350B2SA_Aor_dbTA1.raw	Raw

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Publications

Spatially Characterized Aortic Proteome Reveals Novel Regional Signatures and Glucocorticoid Receptor/Dipeptidase 1 Axis in Diabetic Vasculopathy.

Cheng Chak Kwong CK Meng Shuhui S Li Teng T Ding Huanyu H Jiang Minchun M Tian Zizhao Z Ng Chi-Fai CF Xia Yin Y Offermanns Stefan S Huang Yu Y

MedComm 20260330 4

Diabetes mellitus poses a major global health burden and is intricately linked to cardiovascular complications, yet the spatial molecular landscape of diabetic vasculopathy remains poorly defined. Since thoracic and abdominal aortas differ in embryological origin and hemodynamic microenvironments, we applied laser-capture microdissection to map their spatial proteomes in health and diabetes, using a multidimensional framework across longitudinal (region) and transverse (disease) axes. This appro ...[more]

PMID: 41930346

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