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Human serum proteomics of pancreatic cancer

ABSTRACT: We analyzed a total of 60 human serum samples, including healthy controls, patients with intraductal papillary mucinous neoplasms, and patients with pancreatic ductal adenocarcinoma. Parallel reaction monitoring liquid chromatography–tandem mass spectrometry was performed for quantitative analysis.

INSTRUMENT(S):

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Blood Serum

DISEASE(S): Pancreatic Cancer

SUBMITTER: Min-Jung Kang

LAB HEAD: Min-Jung Kang

PROVIDER: PXD067770 | Pride | 2026-06-08

REPOSITORIES: Pride

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			Action	DRS
	PRM_targets.csv	Csv
	S1.raw	Raw
	S10.raw	Raw
	S11.raw	Raw
	S12.raw	Raw

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Publications

Mass Spectrometry-Driven Proteomic Biomarkers for Serum-Based Detection of Pancreatic Ductal Adenocarcinoma and Intraductal Papillary Mucinous Neoplasm-Associated Invasive Carcinoma.

Jung HyunGyo H Park Namyoung N Kim Jaihwan J Kang Min-Jung MJ

Cancer medicine 20260501 5

<h4>Background</h4>Pancreatic cancer remains a highly lethal malignancy due to late diagnosis and the lack of effective non-invasive biomarkers for detection, further complicated by biological heterogeneity, including intraductal papillary mucinous neoplasm (IPMN) and IPMN-associated invasive carcinoma (IPMC).<h4>Methods</h4>Serum samples from a discovery cohort (n = 60), including patients with IPMN, IPMC, and pancreatic ductal adenocarcinoma (PDAC), were analyzed using LC-MS/MS-based serum pro ...[more]

PMID: 42136141

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Human serum proteomics of pancreatic cancer

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Visium Spatial Transcriptomics expression profiles from IPMN samples of the pancreas

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Improved Detection of Circulating Epithelial Cells in Patients with Intraductal Papillary Mucinous Neoplasms

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Quantitative Proteomic Analysis of Pancreatic Cyst Fluid Proteins Associated with Malignancy in Intraductal Papillary Mucinous Neoplasms

Project description:Intraductal papillary mucinous neoplasm (IPMN) is a benign tumor that grows within the pancreatic ducts characterized by the production of thick mucinous fluid by surrounding tumor cells. IPMN is the most important precursor lesion for pancreatic cancer that is the fourth most common cause of cancer deaths. Differentiating between low-grade dysplasia (LGD), high-grade dysplasia (HGD), and invasive intraductal papillary mucinous neoplasms (IPMNs) remains a diagnostic challenge with current biomarkers, necessitating the development of novel biomarkers that can distinguish IPMN malignancy. We investigated differentially expressed proteins among pancreatic cyst fluids consisted of LGD, HGD, and invasive IPMN patients by using our novel proteomic strategy, and finally we discovered pancreatic cyst fluid protein marker candidates that can predict the malignant potential of IPMNs.

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Effect of mutant GNAS expression in the doxycycline-inducible Kras;Gnas mouse model of IPMN using scRNA-seq

Project description:We investigated the effect of GNAS(R201C) expression in the Kras;Gnas model of pancreatic intraductal papillary mucinous neoplasms where transgenic mutant GNAS is doxycycline inducible (LGKC; p48(Cre), Kras(LSL-G12D), Rosa26(LSL-rtTA)), Tg(TetO-GNAS(R201C)) using scRNA-seq of dissociated pancreatic tissues.

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Effect of mutant GNAS expression in doxycycline-inducible murine pancreatic cancer cell lines

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Expression data from epithelial cells during the process of multistep pancreatic carcinogenesis

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Expression data from epithelial cells during the process of multistep pancreatic carcinogenesis

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2010-12-23 | E-GEOD-19650 | biostudies-arrayexpress