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Quantitative proteomics analysis of Stra8-Pdcd5-/- mouse elongating spermatids

ABSTRACT: In order to investigate the molecular mechanism of PDCD5 in the regulation of spermatids development, elongating spermatids from Pdcd5F/F and Stra8-Pdcd5-/- mice were collected for quantitative proteomics analysis using TMT-based liquid chromatography-tandem mass spectrometry (LC-MS/MS) approach. A total of 8730 proteins were quantified, and 512 proteins (p < 0.05, Foldchange > 1.5) were differentially expressed. Among these differential proteins, 58 proteins were downregulated (11%) and 454 proteins were upregulated (89%) in Stra8-Pdcd5-/- elongating spermatids.

INSTRUMENT(S):

ORGANISM(S): Mus Musculus (mouse)

SUBMITTER: Yueshuai Guo

LAB HEAD: Xuejiang Guo

PROVIDER: PXD067835 | Pride | 2026-01-08

REPOSITORIES: pride

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			Action	DRS
	Search.rar	Other
	TMT_95min_mouse_ES_Pdcd5_fraction10_20191119.raw	Raw
	TMT_95min_mouse_ES_Pdcd5_fraction11_20191119.raw	Raw
	TMT_95min_mouse_ES_Pdcd5_fraction12_20191120.raw	Raw
	TMT_95min_mouse_ES_Pdcd5_fraction13_20191120.raw	Raw

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