Proteomics

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NAT10-mediated ac4C-modification exacerbates ferroptosis by stabilizing HMOX1 in Deep vein thrombosis

ABSTRACT: In our study, we aimed to identify the pathways and genes closely related to DVT. Through proteomic analysis, we found that the ferroptosis signaling pathway showed differential expression, and we also discovered that NAT10 (a key acetyltransferase modified by ac4C) was significantly overexpressed in DVT mice. Based on this discovery, we further investigated the downstream genes regulated by NAT10. We found that NAT10 enhances the stability of HMOX1 through ac4C modification, which results in iron overload and lipid peroxides, thereby forming a positive feedback loop that exacerbates DVT.

INSTRUMENT(S):

ORGANISM(S): Mus Musculus (mouse)

TISSUE(S): Vascular Tissue

SUBMITTER: Yunhong Zhang  

LAB HEAD: Xia Li

PROVIDER: PXD067933 | Pride | 2026-01-26

REPOSITORIES: Pride

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ED161LQ_DVT_1_Slot2-44_1_8093.d.zip Other
ED161LQ_DVT_2_Slot2-45_1_8094.d.zip Other
ED161LQ_DVT_3_Slot2-46_1_8095.d.zip Other
ED161LQ_DVT_4_Slot2-47_1_8097.d.zip Other
ED161LQ_DVT_5_Slot2-48_1_8098.d.zip Other
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NAT10-Mediated ac4C-Modification Exacerbates Ferroptosis by Stabilizing HMOX1 in Deep Vein Thrombosis.

Zhang Yunhong Y   Zhang Zhen Z   Liu Xinkui X   Chu Chu C   Yu Xiaoyan X   Han Qiaoqiao Q   Li Wei W   Zhang Tingting T   Zu Huiyan H   Fan Nannan N   Wei Ran R   Shi Feifei F   Li Fang F   Xu Fei F   Wang Bin B   Li Xia X  

Arteriosclerosis, thrombosis, and vascular biology 20251230 2

<h4>Background</h4>Deep vein thrombosis (DVT) is a prevalent peripheral vascular disorder associated with abnormal epigenetic processes and altered gene expression in endothelial cells. Accumulating evidence has demonstrated that NAT10 (<i>N</i>-acetyltransferase 10)-mediated <i>N</i>4-acetylcytidine modification exerts unique roles in ferroptosis, but its roles are still elusive in DVT.<h4>Methods</h4>To explore the potential mechanism of NAT10 and ferroptosis on thrombogenesis, we used NAT10 a  ...[more]

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