Dataset Information

Proteomic profiling of saliva of periodontally healthy and diseased individuals in young and old age matched groups

ABSTRACT: We used whole saliva samples from periodontally healthy and diseased subjects with chronic periodontitis of to age groups (35–44 years old- group A and B, and 55-64 years old- group C and D) to screen for disease-associated differences in the protein pattern.

INSTRUMENT(S):

ORGANISM(S): Homo Sapiens (human)

SUBMITTER: Elke Hammer

LAB HEAD: Elke Hammer

PROVIDER: PXD068002 | Pride | 2026-06-29

REPOSITORIES: Pride

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Publications

From the Proteome to Therapeutics: A Multi-Database Approach to Drug Discovery in Periodontitis-An Exploratory Pilot Study.

Bozo Taisir T Murr Annette A Holtfreter Birte B Baumeister Sebastian-Edgar SE Meisel Peter P Völker Uwe U Weitschies Werner W Völzke Henry H Kanzow Philipp P Hammer Elke E Salazar Manuela Gesell MG Kocher Thomas T

Journal of clinical periodontology 20260504 7

<h4>Introduction</h4>This explanatory pilot study presents a workflow to identify approved drugs, which could be repurposed for periodontitis therapy using salivary proteomics combined with drug-target database screening.<h4>Methods</h4>Proteomic analyses of saliva using LC-MS/MS were conducted in two independent settings: a cohort (sub-study I, N = 187) and case-control (sub-study II, N = 72). Statistical analyses were performed using both stringent and lenient criteria. Under the stringent (le ...[more]

PMID: 42083475

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