Proteomics

Dataset Information

0

Exosomal protein Profiling in Plasma of DOCA-Salt-Induced Hypertensive and Control Mice

ABSTRACT: This study aimed to profile exosomal protein extracted from plasma of male and female mice treated with DOCA-salt (a model for hypertension) and corresponding baseline controls. The isolated exosomal proteins were sequenced using using LC-MS/MS (Orbitrap Exploris 480+FAIMS Pro). This approach may help identify molecular mechanisms related to sex-specific hypertension responses.This study aimed to profile exosomal protein extracted from plasma of male and female mice treated with DOCA-salt (a model for hypertension) and corresponding baseline controls. The isolated exosomal proteins were sequenced using using LC-MS/MS (Orbitrap Exploris 480+FAIMS Pro). This approach may help identify molecular mechanisms related to sex-specific hypertension responses.

INSTRUMENT(S):

ORGANISM(S): Mus Musculus (mouse)

TISSUE(S): Blood Plasma

SUBMITTER: Vahideh Tarhriz  

LAB HEAD: Vahideh Tarhriz

PROVIDER: PXD068025 | Pride | 2026-02-09

REPOSITORIES: Pride

Json Xml

Dataset's files

Source:
Action DRS
HY-LDF-20230914-FB.msf Msf
HY-LDF-20230914-FB.msfView Msf
HY-LDF-20230914-FB.pdResult Other
HY-LDF-20230914-FB.raw Raw
HY-LDF-20230914-FD.raw Raw
Items per page:
1 - 5 of 8
altmetric image

Publications

Deep learning-driven proteomics analysis for gene annotation in the renin-angiotensin system.

Eivazi Mortaza M   Hosseini Kamran K   Alipanahi Shahin S   Xia Huijing H   Restivo Luke L   Patel Ayushi A   Gozali Mahdieh M   Ebrahimi Tahereh T   Scarborough Amy A   Tarhriz Vahideh V   Lazartigues Eric E  

European journal of pharmacology 20250902

The renin-angiotensin system (RAS) is central to cardiovascular diseases such as hypertension and cardiomyopathy, yet the functions of many RAS genes remain unclear. This study developed a multi-label deep learning model to systematically annotate RAS gene functions and elucidate their roles in biological pathways. A total of 39,463 RAS-related publications from PubMed and PMC were processed into text format. Feature matrices were generated using TF-IDF and token processing, followed by dimensio  ...[more]

Similar Datasets

Genomics Exosomal miRNA Profiling in Plasma and Cerebrospinal Fluid of DOCA-Salt-Induced Hypertensive and Control Mice
2026-03-04 | GSE302573 | GEO
Proteomics Benefits of FAIMS to improve the proteome coverage of hard-to-analyze TMT 10-plex FFPE tissue and plasma-derived exosomes samples
2024-01-26 | PXD042596 | Pride
Proteomics Benefits of FAIMS to improve the proteome coverage of hard-to-analyze TMT 10-plex FFPE tissue and plasma-derived exosomes samples
2024-01-26 | PXD042601 | Pride
Proteomics Benefits of FAIMS to improve the proteome coverage of deteri-orated, and/or cross-linked TMT 10-plex FFPE tissue and plas-ma-derived exosomes samples
2024-01-26 | PXD045362 | Pride
Proteomics Benefits of FAIMS to improve the proteome coverage of hard-to-analyze TMT 10-plex FFPE tissue and plasma-derived exosomes samples
2024-01-26 | PXD042597 | Pride
Proteomics Benefits of FAIMS to improve the proteome coverage of deteriorated, and/or cross-linked TMT 10-plex FFPE tissue and plas-ma-derived exosomes samples
2024-01-26 | PXD045367 | Pride
Proteomics PR8 Sbmut HA library characterization Heaton
2024-04-05 | PXD048318 | Pride
Transcriptomics Preservation of Myogenic Tone in Kidney Microvasculature of Dahl Salt-Sensitive Rats. Role of C-C motif chemokine ligand 2
2026-04-02 | GSE298536 | GEO
Proteomics What does next generation Mass Spectrometry offer for proteomics? A comprehensive platform comparison
2026-04-02 | PXD057442 | Pride
Proteomics A Compact Quadrupole-Orbitrap Mass Spectrometer with FAIMS Interface Improves Proteome Coverage in Short LC Gradients
2020-02-17 | PXD016662 | Pride