Proteomics

Dataset Information

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Fecal detection of calprotectin subunits links IBD activity with chronicity of intestinal inflammation.

ABSTRACT: Quantification of the human S100A8/S100A9 tetrameric protein complex in stool, referred to as fecal calprotectin, is an extensively validated biomarker supporting the diagnosis and management of gastrointestinal diseases1,2. The quaternary protein structures (called configuration here) of S100A8 and S100A9 and their biological function in the human intestine is unknown. This study unravels a diagnostic value for fecal S100A9 detection in IBD and identifies pleiotropic inflammatory mechanisms of S100A8 and S100A9 homodimers in the intestine.

INSTRUMENT(S):

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Feces

DISEASE(S): Gastrointestinal System Disease

SUBMITTER: Leopold Kremser  

LAB HEAD: Bettina Sarg

PROVIDER: PXD068250 | Pride | 2025-12-18

REPOSITORIES: Pride

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870_A8.msf Msf
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Publications

Fecal Detection of Calprotectin Subunits Links Inflammatory Bowel Disease Activity With Chronicity of Intestinal Inflammation.

Jukic Almina A   Hilbe Richard R   Zundel Luis L   Willeit Peter P   Faserl Klaus K   Plattner Christina C   Zollner Andreas A   Meyer Moritz M   Siegmund Kerstin K   Klepsch Victoria V   Marteau Valentin V   Vich Vila Arnau A   Schwärzler Julian J   Vouk Kathrin K   Kozsar Anna A   Rieder Dietmar D   Weichberger Amos A   Sarg Bettina B   Grabherr Felix F   Mayr Lisa L   Moser Patrizia P   Nemati Niloofar N   Scholl-Bürgi Sabine S   Karall Daniela D   Vogel Georg F GF   Welz Lina L   Aldrian Denise D   Koch Robert R   Pfister Alexandra A   Ran Qitao Q   Kaser Arthur A   Blumberg Richard S RS   Tancevski Ivan I   Sommer Felix F   Bacher Petra P   Schreiber Stefan S   Rosenstiel Philip P   Aden Konrad K   Baier Gottfried G   Bakiri Latifa L   Müller Thomas T   Weiss Günter G   Weersma Rinse K RK   Trajanoski Zlatko Z   Wagner Erwin F EF   Tilg Herbert H   Adolph Timon E TE  

Gastroenterology 20251126 3

<h4>Background & aims</h4>Quantification of the human S100A8/S100A9 tetrameric protein complex in stool, referred to as fecal calprotectin, is an extensively validated biomarker supporting the diagnosis and management of gastrointestinal diseases. Here, we studied the quaternary protein structures (termed configuration) of S100A8 and S100A9 and their biological function in inflammatory bowel diseases (IBD).<h4>Methods</h4>We dissected fecal S100A8 and S100A9 configurations in patients with IBD b  ...[more]

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