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Investigating the mechanism of action of IVIG in DSS-induced colitis mice through proteomics.

ABSTRACT: In this study, a mouse model of dextran sulfate sodium (DSS)-induced colitis was employed to investigate the role and mechanism of IVIG by proteomics.

INSTRUMENT(S):

ORGANISM(S): Mus Musculus (mouse)

TISSUE(S): Colon

SUBMITTER: Qian Long

LAB HEAD: Qian Long

PROVIDER: PXD068491 | Pride | 2026-07-28

REPOSITORIES: Pride

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			Action	DRS
	Result.zip	Other
	XA06758DA_C1_1_26826.d.zip	Other
	XA06758DA_C2_1_26827.d.zip	Other
	XA06758DA_C3_1_26829.d.zip	Other
	XA06758DA_D1_1_26831.d.zip	Other

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Publications

Intravenous Immunoglobulin Reveals a Novel Protective Mechanism: Targeting the GBP5-Driven Pyroptosis Axis in Experimental Colitis.

Long Qian Q Wang Tong T He Jia J Yan Xiaochen X Wang Zongkui Z Li Changqing C Zhang Rong R

Pharmaceuticals (Basel, Switzerland) 20260622 6

<b>Background</b>: Ulcerative colitis (UC) is a chronic inflammatory bowel disease characterized by mucosal barrier disruption and dysregulated immune responses. While Intravenous Immunoglobulin (IVIG) is widely used for its immunomodulatory effects in various autoimmune conditions, its specific therapeutic mechanisms and molecular targets in colitis remain to be fully elucidated. <b>Objective</b>: To elucidate the therapeutic mechanisms of IVIG in dextran sodium sulfate (DSS)-induced colitis, w ...[more]

PMID: 42356589

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