Eurasian common shrew liver proteome over the seasons LC-MSMS

ABSTRACT: Eurasian common shrews (Sorex araneus) maintain exceptionally high metabolic rates year-round, posing a significant energetic challenge during winter when food availability declines. To investigate seasonal metabolic regulation, we performed proteomic profiling of liver tissue—central to energy homeostasis—across seasons, using a bottom-up/shotgun DDA LC-MSMS proteomics analytical strategy. This approach reveals molecular adaptations that support metabolic resilience and highlights key regulatory shifts in response to environmental stress. The files and search results are labelled as: Liver___G_Juvanile/Adult_Mouse#1-5 Example: “Liver_2020_07_G_J2” is a liver sample collected in 2020 month 07 from juvenile mouse #2 Liver_2020_07_G_J1-5: summer 2020 Liver_2020_11_G_J1-4: fall 2020 Liver_2021_04_G_A1-5: spring 2021 Liver_2021_06_G_A1-5: summer 2021 By exploring these mechanisms, we offer novel insights into the interplay between metabolism, size, and longevity, shedding light on both the wintering strategy of the common shrew and broader mammalian physiology.

INSTRUMENT(S):

ORGANISM(S): Sorex Araneus

TISSUE(S): Hepatocyte, Liver

SUBMITTER: Tue Bjerg Bennike  

LAB HEAD: Tue Bjerg Bennike

PROVIDER: PXD068559 | Pride | 2025-10-31

REPOSITORIES: Pride