Proteomics

Dataset Information

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Alzheimer’s disease risk and the isoform dependence of phospholipid-apolipoprotein E interaction

ABSTRACT: The ε4 allele of the APOE gene, encoding the E4 isoform of apolipoprotein E, is the leading genetic risk factor for late-onset Alzheimer’s disease. While many potential mechanisms have been proposed to explain this risk, no dominant or unifying process has yet emerged. Here, we explore the primary function of apolipoprotein E in lipid transport and metabolism, by examining its lipid association properties, to establish whether they show isoform dependence and thereby could mediate Alzheimer’s risk. We focus on ethanolamine plasmalogen, a phospholipid subclass known to be depleted in Alzheimer’s disease brain.

INSTRUMENT(S):

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Cerebrospinal Fluid

SUBMITTER: Jenny Hallqvist  

LAB HEAD: Kevin Mills

PROVIDER: PXD068681 | Pride | 2026-03-09

REPOSITORIES: Pride

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Dataset's files

Source:
Action DRS
Discovery_MSE_Identifications.txt Txt
JH_20220310_APOE_Screening_IP_01.raw.zip Raw
JH_20220310_APOE_Screening_IP_02.raw.zip Raw
JH_20220310_APOE_Screening_IP_03.raw.zip Raw
JH_20220310_APOE_Screening_IP_04.raw.zip Raw
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Publications

Plasmalogen deficiency and the Alzheimer's disease risk of apolipoprotein E4.

Hällqvist Jenny J   Taanman Jan-Willem JW   Göteson Andreas A   Heywood Wendy E WE   Schott Jonathan M JM   Hardy John J   Landén Mikael M   Zetterberg Henrik H   Mills Kevin K   Ginsberg Lionel L  

Brain communications 20260212 1

The ε4 allele of the <i>APOE</i> gene, encoding the E4 isoform of apolipoprotein E, is the leading genetic risk factor for late-onset Alzheimer's disease. While many potential mechanisms have been proposed to explain this risk, no dominant or unifying process has yet emerged. Here, we explore the primary function of apolipoprotein E in lipid transport and metabolism, by examining its lipid association properties, to establish whether they show isoform dependence and thereby could mediate Alzheim  ...[more]

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