Proteomics

Dataset Information

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Characterization of MS white matter derived extracellular vesicles

ABSTRACT: This dataset contains proteomic profiles of extracellular vesicles (EVs) isolated from human multiple sclerosis (MS) white matter tissue, alongside the corresponding tissue proteome. The aim of this study is to characterize the protein cargo of MS-derived EVs compared to bulk tissue and to identify molecular features linked to MS pathology. Proteins were labeled using TMTpro 18-plex reagents, fractionated by basic pH reversed-phase LC, and analyzed by Orbitrap Fusion Lumos mass spectrometry.

INSTRUMENT(S):

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Brain

SUBMITTER: Larissa Jank  

LAB HEAD: Pavan Bhargava

PROVIDER: PXD068695 | Pride | 2025-11-17

REPOSITORIES: Pride

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Dataset's files

Source:
Action DRS
101723_human_MS_EV_proteome_F24.msf Msf
101723_human_MS_EV_proteome_F24_Proteins_perse2.csv Csv
101723_human_MS_EVandTissue_RAW.zip Other
101723_human_MS_total_proteome_F24.msf Msf
101723_human_MS_total_proteome_F24_Proteins_perse2.csv Csv
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Publications

Extracellular Vesicles From Multiple Sclerosis White Matter Exhibit Synaptic, Mitochondrial, Complement and Ageing-Related Pathway Dysregulation.

Jank Larissa L   Kumar Madathiparambil Kumaran Satheesh MKS   Ryu Taekyung T   Thapa Rohit R   Gololobova Olesia O   Niepokny Timothy D TD   Calabresi Peter A PA   Witwer Kenneth K   Dutta Ranjan R   Na Chan Hyun CH   Bhargava Pavan P  

Journal of extracellular vesicles 20251101 11

Extracellular vesicles (EVs) are increasingly recognized as mediators of central nervous system (CNS) function and pathologies, including multiple sclerosis (MS). While plasma-derived EVs have been explored as biomarkers in MS, little is known about EVs in CNS tissue. Here, we characterize EVs from postmortem normal-appearing white matter (NAWM) of MS and control brains. EVs were separated by differential centrifugation followed by size exclusion chromatography and characterized using nanoflow c  ...[more]

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