CK2-mediated DEK Phosphorylation Drives PBX3 Overexpression: A Core Event in Hematopoietic Stem Cell-to-Leukemia Stem Cell Transformation

ABSTRACT: 1. LSCs from MLL-AF9-driven DekTg-fl, Tie2-Cre AML mice were sorted, followed by further proteomic assay. 2. To illustrate DEK-interacting proteins, we performed anti-Flag co-immunoprecipitation (co-IP) followed by mass spectrometry using MLL-AF9-driven LSCs to characterize protein interactomes of DEK.

INSTRUMENT(S):

ORGANISM(S): Mus Musculus (mouse)

TISSUE(S): Stem Cell, Bone Marrow

DISEASE(S): Acute Myeloid Leukemia

SUBMITTER: yufei lei  

LAB HEAD: Zhe Chen

PROVIDER: PXD068965 | Pride | 2026-07-06

REPOSITORIES: Pride