Proteomics

Dataset Information

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Alterations in proteome and proteostasis networks during replicative senescence


ABSTRACT: The accumulation of senescent cells constitutes a pivotal hallmark of tissue ageing, contributing to disruption of tissue homeostasis and thus, to the development of several aging-related diseases. Despite this, our knowledge about the molecular, spatial and temporal changes that drive aging on a cellular basis remains poorly understood. To elucidate these mechanisms, we employed mass spectrometry-based proteomics to determine changes in the total proteome, the ubiquitin-modified proteome, the phospho-proteome and in protein solubility during replicative senescence in human IMR90 fibroblasts. This accession number contains the data used in the quantification of different ubiquitin linkage using the SureQuant Technique; for the OtUBD pulldown (control and MG132 treated) and solubility datasets.

INSTRUMENT(S):

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Fibroblast Of Lung

SUBMITTER: Petra Beli  

LAB HEAD: Petra Beli

PROVIDER: PXD069085 | Pride | 2026-07-16

REPOSITORIES: Pride

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