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Resveratrol Suppresses Susceptibility of Ventricular Arrhythmia in Heart Failure Model

ABSTRACT: In a rabbit heart failure model, resveratrol treatment restored cardiac function, normalized calcium handling, and reduced ventricular arrhythmia by reversing ion channel downregulation, fibrosis, apoptosis, and inflammation. These findings highlight resveratrol’s cardioprotective potential as a therapeutic strategy against arrhythmia in heart failure.

INSTRUMENT(S):

ORGANISM(S): Oryctolagus Cuniculus (rabbit)

TISSUE(S): Heart

SUBMITTER: Chen-Chung Liao

LAB HEAD: Chen-Chung Liao

PROVIDER: PXD069110 | Pride | 2026-01-12

REPOSITORIES: Pride

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			Action	DRS
	20241008-micropac110cm-DIA120min-C20240001_N6.raw	Raw
	20241008-micropac110cm-DIA120min-C20240002_N9.raw	Raw
	20241008-micropac110cm-DIA120min-C20240003_N10.raw	Raw
	20241008-micropac110cm-DIA120min-C20240004_HF311.raw	Raw
	20241008-micropac110cm-DIA120min-C20240005_HF327.raw	Raw

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Publications

Resveratrol suppresses susceptibility of ventricular arrhythmia in heart failure model.

Tsai Yung-Nan YN Hsiao Ya-Wen YW Chang Ting-Yung TY Liao Chen-Chung CC Lin Chin-Yu CY Hsieh Yu-Cheng YC Chao Tze-Fan TF Li Guan-Yi GY Huang Yu-Ting YT Higa Satoshi S Chen Shih-Ann SA Chang Shih-Lin SL

BMC cardiovascular disorders 20251204 1

BACKGROUND: This study investigated the efficacy of resveratrol in reducing ventricular arrhythmia (VA) and modulating calcium handling in a heart failure (HF) model. METHODS: HF rabbits were established five weeks after coronary artery ligation. The groups included control, HF rabbits, and HF rabbits treated with intraperitoneal injections of resveratrol 2.5 mg/kg (HF + Res group) in the last week. The electrophysiology of the left ventricle (LV) was investigated using epicardial optical mappin ...[more]

PMID: 41345537

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Titin-dependent transient ventricular defects result in adult atrial arrhythmia and impaired contractility

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2024-08-09 | PXD038300 | Pride

Phytosterol accumulation results in ventricular arrhythmia, impaired cardiac function and death

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Transcription profiling of mouse heart, brain, and skeletal muscle to determine the rffect of age, calorie restriction and resveratrol on gene expression

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Phytosterol accumulation results in ventricular arrhythmia, impaired cardiac function and death

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