Dataset Information

Proteomic profiling of VeA knockout, overexpression, and wild-type strains in Cordyceps

ABSTRACT: This study investigates the proteomic alterations associated with the VeA gene in Cordyceps. Comparative proteomic analysis was performed across wild-type, VeA knockout, and VeA overexpression strains to reveal differentially expressed proteins and pathways related to fungal development, secondary metabolism, and stress responses. The results provide insights into the functional role of VeA in fungal physiology.

INSTRUMENT(S):

ORGANISM(S): Cordyceps Cf. Militaris Chen-1999

TISSUE(S): Mycelium

SUBMITTER: Zhiwei Ouyang

LAB HEAD: Bin He

PROVIDER: PXD069133 | Pride | 2026-01-23

REPOSITORIES: Pride

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Dataset's files

Source:

			Action	DRS
	TXT.zip	Other
	XB10795DA_KOVeA600_Slot1-7_1_21618.d.zip	Other
	XB10795DA_OEVeA4_Slot1-4_1_21612.d.zip	Other
	XB10795DA_WT_Slot1-3_1_21610.d.zip	Other
	checksum.txt	Txt

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Publications

The Velvet protein vea: a key positive regulator of growth and cordycepin biosynthesis in Cordyceps militaris.

Yu Wenbin W Zhou Xiaoyu X Zhang Yufei Y Yao Lihua L Tu Yayi Y He Bin B

Microbial cell factories 20251210 1

Cordyceps militaris (C. militaris) is a prized medicinal fungus and a rich source of bioactive compounds, notably cordycepin. While the cordycepin biosynthetic gene cluster has been identified, the global regulatory networks orchestrating its production remain elusive. Here, we identify the Velvet protein CmVeA as a master regulator that synchronizes fungal development and cordycepin biosynthesis in C. militaris. Overexpression of CmveA significantly enhanced mycelial growth, sporulation, and co ...[more]

PMID: 41372937

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