Characterization of Mast2 Kinase Defines Structural Features, Regulation, and Substrates

ABSTRACT: The mammalian microtubule-associated serine/threonine (MAST) kinases are a highly conserved subfamily of AGC kinases that are implicated as therapeutic targets for cancer and diabetes. However, the activity, regulation, and substrates of MAST kinases are poorly understood. Stable 18O-ATP labeled kinase assay linked phospho-proteomics (SIKALIP) identifies a collection of putative Mast2 substrate. Our results develop a biochemical profile of the MAST Kinases, provide insight into their regulatory mechanisms, and begin to identify the cellular functionof MAST2.

INSTRUMENT(S):

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Epithelial Cell, Cell Culture

SUBMITTER: Michael Lemke Lemke  

LAB HEAD: Thurl Eugene

PROVIDER: PXD069171 | Pride | 2026-01-05

REPOSITORIES: Pride