Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

A secreted AIP-Like peptide from Helcococcus kunzii inhibits the Agr Quorum Sensing System of Staphylococcus aureus

ABSTRACT: In this study, we investigated the impact of the Helcococcus kunzii derived protein Adh2 on S. aureus physiology and pathogenicity.

INSTRUMENT(S):

ORGANISM(S): Staphylococcus Aureus

SUBMITTER: Jean ARMENGAUD

LAB HEAD: Jean Armengaud

PROVIDER: PXD069181 | Pride | 2026-06-17

REPOSITORIES: Pride

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	E08322_MS24-071_Exo_PBS_R1.mgf	Mgf
	E08322_MS24-071_Exo_PBS_R1.raw	Raw
	E08323_MS24-071_Exo_PBS_R2.mgf	Mgf
	E08323_MS24-071_Exo_PBS_R2.raw	Raw
	E08324_MS24-071_Exo_PBS_R3.mgf	Mgf

Items per page:

1 - 5 of 48

Similar Datasets

Fecal microbiota transplant rescues mice from sepsis

Project description:The aim of this study was to test the hypothesis that replenishing the microbiota with a fecal microbiota transplant (FMT) can rescue a host from an advanced stage of sepsis. We developed a clinically-relevant mouse model of lethal polymicrobial gut-derived sepsis in mice using a 4-member pathogen community (Candida albicans, Klebsiella oxytoca, Serratia marcescens, Enterococcus faecalis) isolated from a critically ill patient. In order to mimic pre-operative surgical patient condition mice were exposed to food restriction and antibiotics. Approximately 18 hours prior to surgery food was removed from the cages and the mice were allowed only tap water. Each mouse received an intramuscular Cefoxitin injection 30 minutes prior to the incision at a concentration of 25 mg/kg into the left thigh. Mice were then subjected to a midline laparotomy, 30% hepatectomy of the left lateral lobe of the liver and a direct cecal inoculation of 200 µL of the four pathogen community. On postoperative day one, the mice were administered rectal enema. Mice were given either 1 ml of fecal microbiota transplant (FMT) or an autoclaved control (AC). This was again repeated on postoperative day two. Mice were then followed for mortality. Chow was restored to the cages on postoperative day two, approximately 45 hours after the operation. The injection of fecal microbiota transplant by enema significantly protected mice survival, reversed the composition of gut microflora and down-regulated the host inflammatory response. The cecum, left lobe of the liver, and spleen were isolated from mice for microarray processing with three or more replicates for six expermental conditions: non-treated control, SAHC POD1, SAHC.AC POD2, SAHC.FMT POD2, SAHC.AC POD7, SAHC.FMT POD7

2015-07-30 | E-GEOD-71530 | biostudies-arrayexpress

The expression profile of 5-fluorouracil pathway genes in colorectal carcinoma

Project description:This study addressed involvement of fourteen 5-fluorouracil pathway genes in the prognosis of colorectal carcinoma patients. The major goal of our study was to investigate associations of gene expression of enzymes metabolizing 5-fluorouracil with therapy response and survival of colorectal carcinoma patients Downregulation of DPYD and upregulation of PPAT, UMPS, RRM2, and SLC29A1 transcripts were found in tumors compared to adjacent mucosas in testing and validation sets of patients. Low RRM2 transcript level significantly associated with poor response to the first-line palliative 5-FU-based chemotherapy in the testing set and with poor disease-free interval of patients in the validation set. Testing and validation sets comprising paired tumor and adjacent mucosa tissue samples from 119 patients were used for transcript profiling by quantitative real-time PCR. Intratumoral gene expression levels were correlated with clinical data of patients.

2015-08-31 | E-GEOD-67111 | biostudies-arrayexpress