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Spatial proteomics for the analysis of host-pathogen interactions in mice lungs infected with Aspergillus fumigatus

ABSTRACT: Laser-based tissue microdissection of lungs from mice infected with A. fumigatus and the subsequent MALDI Imaging MS offers the possibility to excise defined regions and transfer them to the more sensitive and deeper LC-MS/MS-based proteome analysis. In case of host-pathogen interaction between mammalian cells and pathogenic fungi like A. fumigatus this combination opens up the possibility to elucidate this biological cross-talk together with spatial Information on the invasive fungal infection. Here, we provide for the first time insights into the in vivo proteome of murine lungs infected by A. fumigatus using MALDI-IMS and laser microdissection.

INSTRUMENT(S):

ORGANISM(S): Neosartorya Fumigata (aspergillus Fumigatus) Mus Musculus (mouse)

TISSUE(S): Lung

SUBMITTER: Thomas Krüger

LAB HEAD: Axel A. Brakhage

PROVIDER: PXD069444 | Pride | 2026-03-24

REPOSITORIES: Pride

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			Action	DRS
	01.msf	Msf
	01_a.raw	Raw
	01_b.raw	Raw
	01_c.raw	Raw
	02.msf	Msf

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