Proteomics

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PATIENTS ANTIBODIES RECOGNIZED TWO ISOENZYMES OF GLYCERALDEHYDE -3P- DESHYDROGENASE OF ECHINOCOCCUS GRANULOSUS s. l. Cloning epitopes and enzymatic analysis in silico

ABSTRACT: Our group is working identifying antigens from E. granulosus s.l by immune-identification and LC-MS/MS methodologies, CE patient sera recognized antigens expressed by cell line from bovine’s protoscolices E .granulouss G1 (EGPE). The antigenic model from EGPE cells showed more sensitivity for patient’s sera reactivity than HF obtained for sheep’s E. granulosus G1 . EGPE cells were growth in liquid media and in biphasic agarose medium forming cysts colonies . This cellular model allows us to study expressed proteins mainly found intracellular (IC) or extracellular (EC) compartments.

INSTRUMENT(S):

ORGANISM(S): Echinococcus Granulosus Group

DISEASE(S): Cystic Fibrosis

SUBMITTER: Maria Pia Valacco  

LAB HEAD: Alicia G Fuchs

PROVIDER: PXD069559 | Pride | 2025-11-24

REPOSITORIES: Pride

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Publications

First In Silico Study of Two <i>Echinococcus granulosus</i> Glyceraldehyde-3-Phosphate Dehydrogenase Isoenzymes Recognized by Liver Cystic Echinococcosis Human Sera.

Agüero Facundo Ariel FA   Maglioco Andrea A   Valacco María Pía MP   Juárez Valdez Alejandra Yaqueline AY   Roldán Emilio E   Paulino Margot M   Fuchs Alicia Graciela AG  

International journal of molecular sciences 20251031 21

Cystic echinococcosis (CE) is an endemic zoonotic disease caused by <i>Echinococcus granulosus</i>, which forms cysts in ungulates' intermediate hosts. Humans are accidental hosts, and CE affects more than one million people worldwide. Imaging remains the diagnostic gold standard, outperforming serological methods. This study presents an in silico analysis of two glyceraldehyde-3-phosphate dehydrogenase (GAPDH) isoenzymes from <i>E. granulosus</i> (EgGAPDH), isolated from a parasite cell line (E  ...[more]

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