Dataset Information
Cellular proteome changes occuring in HeLa human cells upon incubation with retro2-derived chemical probes based on PROTAC technology
Ontology highlight
ABSTRACT:
INSTRUMENT(S):
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Epithelial Cell, Cell Culture
SUBMITTER: 
Jean ARMENGAUD
LAB HEAD: Jean Armengaud
PROVIDER: PXD069615 | Pride | 2026-02-24
REPOSITORIES: Pride
Dataset's files
| Action | DRS | |||
|---|---|---|---|---|
| E09202_Pres-034_DMSO_n1_1.mgf | Mgf | |||
| E09202_Pres-034_DMSO_n1_1.raw | Raw | |||
| E09202_Pres-034_DMSO_n1_1.raw.quant | Raw | |||
| E09203_Pres-034_DMSO_n2_2.mgf | Mgf | |||
| E09203_Pres-034_DMSO_n2_2.raw | Raw |
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Publications
Synthesis and biological evaluation of Retro-2-based PROTACs reveal PEG-linker length and warhead impact on GSPT1 degradation.
European journal of medicinal chemistry 20260205
PROteolysis TArgeting Chimeras are attracting growing interest in pharmaceutical research thanks to their catalytic and irreversible mechanism, which is capable of targeting proteins previously considered "undruggable". These bifunctional molecules hijack the cellular ubiquitin-proteasome system by recruiting E3 ligases (such as CRBN or VHL) to induce the selective degradation of a target protein. Their efficacy has been demonstrated against various disorders and several compounds have reached p ...[more]
