Dataset Information

Proteomic analysis of healthy human Aqueous Humour, Anterior Lens Capsules, and Crystalline Lenses

ABSTRACT: Participants were recruited from the Ophthalmology Department among patients scheduled for cataract surgery. Patients were stratified into four distinct groups based on their clinical profiles. ARC group (Age-Related Cataract) included individuals over the age of 75 without a history of diabetes; DC group (Diabetic cataract) included individuals un-der the age of 65 with a known diagnosis of type 1 or type 2 diabetes mellitus; PVC group (Post-Vitrectomy cataract) included individuals of any age, without diabetes, who had undergone vitrectomy with gas tamponade for retinal detachment within the previous 12 months and who had clear lens prior to vitrectomy; and the control group included indi-viduals under the age of 60, without diabetes, who underwent clear lens extraction for re-fractive reasons.

INSTRUMENT(S):

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Eye

SUBMITTER: Martina Samiotaki

LAB HEAD: Christina Karakosta

PROVIDER: PXD069667 | Pride | 2025-12-01

REPOSITORIES: Pride

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Publications

Comparative Proteomic Analysis of Aqueous Humor, Anterior Lens Capsules, and Crystalline Lenses in Different Human Cataract Subtypes Versus Healthy Controls.

Karakosta Christina C Samiotaki Martina M Bisoukis Anastasios A Bougioukas Konstantinos I KI Panayotou George G Kyriakidou Nantieznta N Moschou Konstantinos K Moschos Marilita M MM

Proteomes 20251121 4

<h4>Background</h4>The aim of this study is to investigate the pathophysiology of cataract by analyzing signaling pathways in three sample types obtained from four different lens groups: age-related (ARC), diabetic (DC), post-vitrectomy cataract (PVC) and clear control lenses.<h4>Methods</h4>Three sample types-the aqueous humor, the anterior capsule and the phaco cassette content-were collected during cataract surgery from 39 participants (ARC = 12, DC = 11, PVC = 7 and control = 9). The samples ...[more]

PMID: 41283652

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