Structural proteomics reveals that misfolded nascent proteins expose buried lysines for ubiquitination and rapid proteasomal degradation

ABSTRACT: In this study, we combine structural proteomics and time-resolved isotopic labeling to profile the modification sites, dynamics, and conformational properties of the human ubiquitinome.

INSTRUMENT(S):

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Fibroblast

SUBMITTER: Anushka Jain  

LAB HEAD: Sina Ghaemmaghami

PROVIDER: PXD069668 | Pride | 2026-04-26

REPOSITORIES: Pride