Proteomics

Dataset Information

Syntaxin 4 (STX4) protects islet -cells from cytokine-induced senescence

ABSTRACT: Syntaxin 4 (STX4) is a plasma membrane SNARE protein known to facilitate insulin granule exocytosis in pancreatic β-cells. Recent studies have uncovered that STX4 also exerts protective effects against inflammatory and metabolic stress by stabilizing mitochondrial function and suppressing NF-κB activation. In this project, we investigated the role of β-cell STX4 in modulating the secretome and paracrine signaling under pro-inflammatory conditions associated with β-cell senescence and type 1 diabetes.

INSTRUMENT(S):

ORGANISM(S): Mus Musculus (mouse)

TISSUE(S): Pancreatic Islet Cell

DISEASE(S): Type 1 Diabetes Mellitus

SUBMITTER: Nathaniel Hansen  

LAB HEAD: Dr Patrick Pirrotte

PROVIDER: PXD069706 | Pride | 2026-02-25

REPOSITORIES: Pride

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Dataset's files

Source:
Action DRS
090_0014_01B_R_Sample10_09AUG24_CELL_MOU_ECL_0003_01AA_120MIN_KAD_RS_01.pdResult Other
090_0014_01B_R_Sample10_09AUG24_CELL_MOU_ECL_0003_01AA_120MIN_KAD_RS_01.raw Raw
090_0014_01B_R_Sample20_09AUG24_CELL_MOU_ECL_0003_01AA_120MIN_KAD_RS_01.pdResult Other
090_0014_01B_R_Sample20_09AUG24_CELL_MOU_ECL_0003_01AA_120MIN_KAD_RS_01.raw Raw
090_0014_01B_R_Sample22_09AUG24_CELL_MOU_ECL_0003_01AA_120MIN_KAD_RS_01.pdResult Other
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