The Calmodulin/Striatin Interaction is Enhanced in Diabetic Hearts and Defines Novel Signaling Clusters implicated in Cardiac Remodeling

ABSTRACT: Diabetic cardiomyopathy (DbCM) halts cardiac performance with a complex etiology, hence the absence of an effective therapy for this disease. Herein we decoded the proteins hub interconnected with Calmodulin (CaM), a striatin (STRN) binding protein, that plays a role in DbCM. Using CaM as a bait, we precipitated protein clusters from left ventricles (LVs) of diabetic hearts at two stages of diabetes; 8- and 24-weeks rats treated with streptozotocin-STZ. Diabetic rats showed pathological heart remodeling confirmed by increased heart/body weight (HW/BW) ratio and increased β-MHC protein levels and ANF mRNA expression.

INSTRUMENT(S):

ORGANISM(S): Rattus Norvegicus (rat)

TISSUE(S): Heart

DISEASE(S): Type 2 Diabetes Mellitus

SUBMITTER: Liaqat Ali  

LAB HEAD: Moni Nader

PROVIDER: PXD069737 | Pride | 2026-06-15

REPOSITORIES: Pride